Our previous studies have identified that circulating B7H3 levels in the cerebrospinal fluid (CSF) and plasma of children with bacterial meningitis are helpful markers to differentiate bacterial from aseptic meningitis, and circulating B7H3 level was demonstrated to be useful in evaluating the intensity of the infectious inflammatory process in the central nervous system of children [10]. This evidence concerns the gene CD276 and aseptic meningitis.