SMG1 and cancer: Most of the studies revealed MAGI2-AS3 may function in cancers as a competing endogenous RNA for miRNAs (such as miR-374a/b-5p [28, 31], miRNA-23a-3p [33], and miR-15b-5p [29]) to regulate their target genes (such as CADM2 [28], SMG1 [31], PTEN [33], and CCDC19 [29]), while few indicated MAGI2-AS3 may directly interact with target gene KDM1A [34].