The inconsistency between the expression level and the expected prognosis in the other five genes (RHPN1-AS1, MELK, EIF5AL1, and G6PC3: upregulated, but HR < 1; NLGN2: downregulated, but HR > 1) may be attributed to a protective response mechanism in order to resist the development of cancer. The gene discussed is NLGN2; the disease is cancer.