However, we found that five (RRM2, TXNRD1, DTYMK, UCK2 and ENTPD2 ) of the nine MRGs were enriched in the purine metabolism and pyrimidine metabolism pathways, which was an important finding and indicated that the purine and pyrimidine metabolism pathways had a significant impact on the prognosis of HCC. The gene discussed is RRM2; the disease is hepatocellular carcinoma.