The hypercoagulable state in COVID-19 was confirmed in a study by Han et al., in which higher levels of d-dimer, fibrinogen, and fibrinogen degradation products [46], prolonged prothrombin time (PT), international normalized ratio (INR), and thrombin time (TT) were also noted in patients with COVID-19 [47]; these abnormalities have been associated with poor prognosis in patients infected with SARS-CoV-2 [48]. Here, F2 is linked to COVID-19.