For the SNG pretreatment group, the levels of TNF-α, IL-1, TLR4 mRNA, and NF-κB mRNA in the lung tissue decreased significantly, indicating that SNG pretreatment reduced the inflammatory response of septic ALI, and the specific mechanism might be related to blocking the TLR4/NF-κB signaling pathway. The gene discussed is NFKB1; the disease is acute respiratory distress syndrome.