Curcumol seems to induce cell cycle arrest at G2/M and G0/G1 phases of breast cancer cells and inhibits NF- Kβ pathway through the eliminating the protein kinase B/c-Jun N-Terminal kinases 1/2 (Akt/JNK1/2) pathway and disallowance of MMP9 (63). This evidence concerns the gene MAPK8 and breast carcinoma.