AKT1 and cancer: The differentiation-inducing effect of genistein seems to arise from the activation of phosphatidylinositol 3-kinase/ Protein Kinase B (PI3K/Akt) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK/ERK) signaling pathways through paracrine factors that have been released from ER+ cancer cells (82).