A similar data was previously reported in which Apigenin decreased the expression of phospho Janus Kinase 1/2 (phospho-JAK1/ JAK2), phospho-STAT3, and STAT3-dependent luciferase reporter gene activity in human epidermal growth factor receptor 2 (HER2)- expressing BT- 474 cancer cells (46). This evidence concerns the gene STAT3 and cancer.