The transcription factor, Nrf2 (nuclear factor erythroid-derived 2-like 2), is a critical regulator for maintaining structural and functional integrity of the heart under conditions of abnormal stress [19], and also, it is an important component in antioxidant defense in cardiovascular diseases such as atherosclerosis, hypertension, and heart failure [19, 20]. Here, NFE2L2 is linked to atherosclerosis.