Six protein targets (i.e., MAPT, BACE1, APP, SNCA, MAOA, and MAOB) were categorized in “Alzheimer's disease,” and five targets (i.e., ACHE, CHRM1, CHRNA4, CHRNB2, and FOS) were grouped to “cholinergic synapse,” while another three targets (i.e., CASP8, FOS, and COX-2) were grouped to “TNF signaling pathway”. This evidence concerns the gene CASP8 and early-onset autosomal dominant Alzheimer disease.