Based on immunohistochemical staining (Figures 2(a)), 49 of 94 (52.13%) ccRCC tissues exhibited positive SPON2 staining, whereas 22 of 94 (23.40%) normal tissues exhibited positive SPON2 staining (P < 0.05) (Table 1). This evidence concerns the gene SPON2 and nonpapillary renal cell carcinoma.