SPON2 and nonpapillary renal cell carcinoma: As shown in Figure 4(d), patients with localized ccRCC that presented recurrence could be predicted with a sensitivity of 90.0% at specificity of 77.4% (AUC = 0.844, 95% CI, 0.686−1.000) by SPON2 mRNA (cut − off value = 1.956).