Rescue experiments elucidated that the expression of IFITM3 was remarkably restored when miR-152-3p and KLF4 were simultaneously silenced, indicating that miR-152-3p might affect the IFITM3 expression by targeting KLF4, thus regulating colon cancer cell proliferation and growth. The gene discussed is KLF4; the disease is malignant colon neoplasm.