Familial glucocorticoid deficiency (FGD) (OMIM #202200), a type of primary adrenal insufficiency (PAI), is an autosomal recessive disorder, known as isolated glucocorticoid deficiency or hereditary unresponsiveness to adrenocorticotropic hormone (ACTH) occur during early childhood and neonatal periods [1, 2]. The gene discussed is POMC; the disease is familial glucocorticoid deficiency.