MAPT and Alzheimer disease: As previously discussed, a current model of AD synaptic dysfunction proposes that (1) Aβ42 oligomers induce abnormal kinase activation, (2) leading to Tau hyperphosphorylation and (3) translocation from the axon to the dendritic spines causing (4) LTP blockade, (5) progressive synaptic dysfunction, (6) progressive dendritic spine loss, and (7) early network dysfunction.