The TT genotype of the SNP rs737054 in FKBP5 was significantly associated with TESI in the crude analysis and also after adjustment (OR = 2.36, 95% CI = [1.04; 5.32]; p-value = 0.04; model 1, Table 2), except when adjusted for depression severity changes (p-value = 0.06; model 2, Table 2). This evidence concerns the gene FKBP5 and major depressive disorder.