Abnormal glucose test (N = 33), colonic polyps (N = 29), dysmetabolic syndrome X (N = 11), and urinary cast (N = 10) were among the most frequent traits among MC4R carriers that while suggestive, did not achieve significance (P < 0.001)(Supplementary Table S11a, b). The gene discussed is MC4R; the disease is colon inflammatory polyp.