In this study, we observed that some of the top drivers of the 5 AD-associated modules (Table S4) were linked to AD pathology in regression and random forest analyses on the same cohort; these included C-C motif chemokines from the red module associated with left hippocampal atrophy; carbonic anhydrase III and peptidoglycan recognition protein 1 from the lightgreen module correlated with AD diagnosis [27]. Here, CA3 is linked to Alzheimer disease.