MAPT and Brain atrophy: However, although there was no information on β-amyloid or tau biomarkers (A/T biomarkers), this study provided neuroimaging data (an N biomarker, neuroimaging to measure brain atrophy) including volumes of hippocampi and entorhinal cortices, as well as data on the ROD in AD, which captured different stages of disease pathology including the early preclinical stages.