Moreover, the loss of the homeostatic microglial signature (e.g., Sall1, Pu.1, Tmem119, Cx3cr1, and P2ry12) is associated with CNS disorders [66]; thus, we sought to characterize myeloid cell surface marker expression and morphology following irradiation and microglial replacement. Here, P2RY12 is linked to central nervous system disorder.