Although the time spent in the border zone of the open field arena did not change after infection in both wildtype and Irf-7−/− mice (WT d0 58.33 ± 2.51 %, WT d14 52.19 ± 2.78 %, p = 0.09; Irf-7−/− d0 75.11 ± 2.78 %, Irf-7−/− d14 76.39 ± 2.26%, p = 0.74), it was higher in non-infected and infected Irf-7−/− mice as compared to the respective wildtype mice (p < 0.001, Fig. 3c). The gene discussed is IRF7; the disease is infection.