IRF7 and infection: In contrast, LGTV infection of Irf-7−/− mice had no impact on time spent in the closed arms (and number of entries in the open arms) compared to uninfected Irf-7−/− mice (Fig. 4a–c) (time in closed arms uninfected Irf-7−/− 79.24 ± 3.75, infected Irf-7−/− 77.83 ± 3.40, p = 0.77; entries in open arms: uninfected Irf-7−/− 9.25 ± 1.57, infected Irf-7−/− 12.33 ± 1.66, p = 0.14).