The relationship between objectively recorded ELS and self‐reporting, and the average BDI score (mean of time 1 and time 2) or mild to severe BDI scores, or both, were moderated by the FKBP5 variants.FKBP5 variations combined with and objectively recorded ELS and self‐reporting could predict more noticeable depression symptoms in midlife.26 This evidence concerns the gene FKBP5 and major depressive disorder.