The relationship between objectively recorded ELS and self‐reporting, and the average BDI score (mean of time 1 and time 2) or mild to severe BDI scores, or both, were moderated by the FKBP5 variants.FKBP5 variations combined with and objectively recorded ELS and self‐reporting could predict more noticeable depression symptoms in midlife.26 Here, FKBP5 is linked to depressive symptom measurement.