Yuan et al. in 2019 identified 2 novel ADGRG2 mutations in 10 CBAVD patients without CFTR mutations (Yuan et al., 2019) and Wang et al. identified one ADGRG2 mutations in 38 CBAVD patients (Wang et al., 2020) in Chinese populations. This evidence concerns the gene CFTR and congenital bilateral aplasia of vas deferens from CFTR mutation.