The mechanisms for the role of NRP‐1 in cancer progression rely on its interactions with several key signalling pathways in cancer cells, such as transforming growth factor β1 (TGFβ1), semaphorin (Sema), vascular endothelial growth factor (VEGF), hedgehog (HH), interferon‐γ (IFNγ) and GAIP/RGS19‐interacting protein (GIPC1).15, 16, 17, 18, 19, 20. The gene discussed is NRP1; the disease is cancer.