To confirm whether positive intervention of Sirt3 leads to the reduction in oxidative stress and delay in hematopoietic aging, and to determine whether Sirt3 expression is a downstream event of autophagic protection, we performed ectopic expression of Sirt3 by lentivirus infection in the hematopoietic Atg7‐deleted mice. This evidence concerns the gene ATG7 and lentivirus infection.