Natural Killer (NK) cell activation was required for development of significant hepatic fibrosis in GNMT‐/‐ mice (Gomez‐Santos et al., 2012) and more recently cell death‐mediated by TNF‐related apoptosis‐inducing ligand (TRAIL) secreting NK cells were necessary for fibrosis in this mouse model (Fernandez‐Alvarez et al., 2015). This evidence concerns the gene GNMT and Hepatic fibrosis.