HMGB1 and Sepsis: Another way to trigger activation of coagulation and exacerbate inflammation in sepsis is via damage‐associated molecular pattern (DAMP), such as, extracellular histones,45 nucleic acids46 and high mobility group box 1 (HMGB1)47 molecules that are released during cell death or shear‐induced neutrophil extracellular trap (NETs) release.48