During sepsis, multiple events feed into this amplification loop, where glycocalyx is shedding, endothelium becomes dysfunctional, vessels become leaky, hypotension causes low shear rate and SS, while there is systemic inflammation, complement activation, increased leucocyte adhesion and hypercoagulation due to TF expression and imbalanced anticoagulants (thrombomodulin, AT and TFPI). The gene discussed is THBD; the disease is Sepsis.