High USP1 expression was associated with poor overall survival (OS, HR = 1.76 (1.24‐2.48), log‐rank P = .0012), relapse‐free survival (RFS, HR = 1.57 (1.13‐2.19), log‐rank P = .0063), progression‐free survival (PFS, HR = 1.7 (1.27‐2.28), log‐rank P = .00035) and disease‐specific survival (DSS, HR = 1.94 (1.24‐3.04), log‐rank P = .0031) of HCC patients (Figure 3A‐D). Here, USP1 is linked to hepatocellular carcinoma.