CALR and myeloproliferative disorder: Nam et al. developed genotyping of transcriptomes, a method to integrate genotyping with droplet-based single-cell transcriptomes, and used it to profile ~40,000 CD34+ cells from patients with CALR-mutated myeloproliferative neoplasms, identifying an association between the activation of the unfolded protein response and NF-κB pathway with CALR mutations [54].