In this study, we found that the expression of circFoxp1 and Foxp1 in colon cancer tissues was negatively correlated, and circFoxp1 hypermethylated the promoter of Foxp1 by recruiting DNMT1, thereby inhibiting the expression of Foxp1, and ultimately promoting the colon cancer progress. Here, DNMT1 is linked to malignant colon neoplasm.