COMT and bipolar disorder: We examined SNPs of the COMT gene to evaluate whether brain responses elicited by the DS-CPT may be specifically associated with a select aspect of genetic variation that has been related to both schizophrenia and bipolar disorder (Docherty and Sponheim, 2008, Goghari and Sponheim, 2008, Silberschmidt and Sponheim, 2008, Venables et al., 2009).