A number of studies have related the Val158Met COMT single nucleotide polymorphism (SNP) to both schizophrenia and poor performance on cognitive tasks associated with frontal lobe function (Egan et al., 2001, Fan et al., 2005, Malhotra et al., 2002, Winterer et al., 2006). The gene discussed is COMT; the disease is schizophrenia.