The results of the multivariate analysis revealed that after the adjustment for age-squared, gender, hemoglobin, eGFR, LVEF, and log BNP, the presence of T2DM was an independent predictor of lowered peak VO2 in the CHF patients with LVEF ≥ 40% and in those with LVEF < 40% (Table 4). Here, NPPB is linked to type 2 diabetes mellitus.