The studies from NTHL1 families (Grolleman et al., 2019; Kuiper & Hoogerbrugge, 2015; Weren et al., 2015) add evidence for this: the same causative gene defect(s) in either recessive or dominant mode of inheritance, depending on the colorectal cancer/polyposis syndrome in concern, can also lead to predisposition to cancer in various different tissues. This evidence concerns the gene NTHL1 and cancer.