For example, the eligibility criteria in PARADIGM‐HF included elevated natriuretic peptides: BNP ≥150 pg/ml or NT‐proBNP ≥600 pg/ml (for patients with HF hospitalization within 12 months, BNP ≥100 pg/ml or NT‐proBNP ≥400 pg/ml), that is, a factor of 4. Here, NPPB is linked to hydrops fetalis.