Increased NE primarily activates the tumor cell cyclic AMP (cAMP)-protein kinase A (PKA) signaling pathway by β2-receptor activation on ovarian cancer cells to trigger an increase in the expression of the vascular endothelial growth factor (VEGF) gene, resulting in enhanced tumor vascularization and aggressive growth and spread of malignant cells. This evidence concerns the gene VEGFA and ovarian carcinoma.