While previous studies have pointed toward a significant association of CHIP mutations (like DNMT3A and TET2) with the risk of CAD [18, 19], progression of degenerative aortic valve stenosis [21], and impaired prognosis in patients with heart failure [20], this study is the first to suggest that IDH1 mutations are also associated with CAD and cardiac dysfunction in established AMLs. This evidence concerns the gene TET2 and coronary artery disorder.