IDH1 and acute myeloid leukemia: When comparing IDH1/2wildtype and pooled IDH1/2mutated AML patients in the weighted study cohort (model 2), the pooled IDH1/2mutated group showed a reduced LVEF after the initiation of AML therapy (in t2 and t3; e.g., t3: absolute LVEF reduction −13.5%, 95%CI −20.94 to −6.06, p < 0.0001) compared to IDH1/2wildtype AML patients (Fig. 4c and Supplementary Table S6 in the Data Supplement), suggesting a possible link between mutations in the IDH1/2 genes of hematopoietic cells in AML and an impaired LVEF following initiation of AML therapy after achieving covariate balance.