When comparing (IDH1/2wildtype versus IDH1mutated) in the unweighted study cohort, cardiac function declined at different time points following AML therapy in IDH1/2wildtype and IDH1mutated patients, while IDH1 mutation was significantly related with deterioration of cardiac function following the initiation of AML therapy (t2–3, e.g., t2: absolute LVEF reduction −16.8%, 95%CI −27.59 to −6.01, p = 0.002) (Fig. 4e and Supplementary Table S7 in the Data Supplement). This evidence concerns the gene IDH1 and acute myeloid leukemia.