ACE and cancer: [3, 36–38] In this study the stronger decrease in LVEF (up to −8.3% to −16.8%) in IDH mutated AML patients during treatment might be of clinical importance since in line with the definition of cardiotoxicity commonly used, cancer treatment-related cardiac dysfunction is relevant with a decrease in the LVEF of 10 percentage points and these patients have a better cardiac outcome when treated with ACE inhibitors and/or beta-blockers early after detection of cardiac dysfunction [36, 39, 40].