While previous studies have pointed toward a significant association of CHIP mutations (like DNMT3A and TET2) with the risk of CAD [18, 19], progression of degenerative aortic valve stenosis [21], and impaired prognosis in patients with heart failure [20], this study is the first to suggest that IDH1 mutations are also associated with CAD and cardiac dysfunction in established AMLs. The gene discussed is DNMT3A; the disease is heart failure.