In the corresponding unweighted study cohort, the mean LVEF declined at different time points during AML therapy in both groups with significantly reduced ejection fraction in IDH1/2mutated AML compared to IDH1/2wildtype patients after the initiation of AML therapy (t2–3, e.g., t3: absolute LVEF reduction −8.8%, 95%CI −18.80 to 1.20, p = 0.028) (Fig. 4d and Supplementary Table S6 in the Data Supplement). The gene discussed is IDH1; the disease is acute myeloid leukemia.