Among downregulated DEGs in Ubc9+/− Lgr5-EGFP+ cells, up to 17% were genes found to be repressed in early gastric cancer, colorectal adenocarcinoma, E2F1-overexpressing hepatocellular carcinoma and a subtype of basal breast cancer. The gene discussed is LGR5; the disease is colorectal adenocarcinoma.