RYR2 and cardiomyopathy: Indeed, CaMKII activity and subsequent RyR2 phosphorylation on the critical serine residue (Ser2814), which has been linked to CaMKII-mediated Ca2+ leak in cardiomyopathy and catecholamine treatment41, was significantly attenuated by NO2-OA in Iso-stressed cardiomyocytes (Fig. 6B).