Each tumor expresses typical sets of GPCRs: (1) GPR4 is expressed on all epidermal portions of NCN (IHC: 40% ++, 60% +, TMA: 38.9% ++, 61,1% +) and on epidermal (IHC: 20% ++, 40% +, TMA: 94.7% ++, 5.3% +) and dermal (IHC: 60% ++, 40% +, TMA: 52.6% ++, 15.8% +) MM. The gene discussed is GPR4; the disease is neoplasm.