TNFRSF25 and obesity due to melanocortin 4 receptor deficiency: Analysis of the same metabolic parameters in BALB/c mice (Supplementary Fig. 1) are in agreement with the findings in C57BL/6J mice, indicating DR3-depedent stimulation of ILC2s significantly limits the onset of obesity, improves glucose homeostasis and insulin resistance in mice independent of the genetic background.