TNFRSF25 and type 2 diabetes mellitus: Taken together, these results demonstrate that DR3 stimulation of ILC2s improves glucose homeostasis and protects from onset of type 2 diabetes through beiging of the adipose tissue, abrogating both adipocyte hypertrophy and hyperplasia, and promoting VAT-associated AAM phenotype in the absence of B and T cells in vivo.