Insofar as e4 promotes protein aggregation in AD and e2 may reduce it, we examined the impact of these APOE alleles on AD and other proteinopathies including Lewy body dementia involving alpha-synuclein, frontotemporal lobar degeneration (FTLD) related 3R and 4R tau inclusion bodies, TDP-43 cytosolic inclusion bodies, and argyrophilic grain disease. The gene discussed is TARDBP; the disease is Alzheimer disease.