For both amyloid pathologies and tau Braak stage, we observed a significant genotype-severity association: a higher proportion of e2/e4 cases had more severe pathologies than did e2/e3 or e3/e3 cases, but this proportion was similar to that found for e3/e4 cases (all Chi square ps < 0.0001 as in Supplementary Tables 5–7). Here, MAPT is linked to amyloidosis.