SIRT1 and endothelial dysfunction: Recently, anagliptin, a novel DPP-4 inhibitor licensed for treating T2DM, was found to restore HG-induced endothelial dysfunction via SIRT1-dependent inhibition of NLRP3 inflammasome activation and suppression of NOX4–ROS–TXNIP–NLRP3 signaling, which suggests that anagliptin may have broad pharmacological effects in cardiovascular diseases and other metabolic disorders98.