Recently, anagliptin, a novel DPP-4 inhibitor licensed for treating T2DM, was found to restore HG-induced endothelial dysfunction via SIRT1-dependent inhibition of NLRP3 inflammasome activation and suppression of NOX4–ROS–TXNIP–NLRP3 signaling, which suggests that anagliptin may have broad pharmacological effects in cardiovascular diseases and other metabolic disorders98. The gene discussed is NLRP3; the disease is cardiovascular disorder.