Finally, in order to confirm the axis of miR-99b-mTOR and/or κB-ras2 and miR-99b-mTOR/IRF4 in vivo, we detected the expression of κB-ras2, mTOR and IRF4 in TAMs sorted from tumor-bearing mice after delivery of saline, miR-99b, V&Ctrl and V&miR-99b. This evidence concerns the gene MTOR and neoplasm.