MTOR and cancer: More importantly, we found that the expression of mTOR and κB-Ras2 was higher in sorted TAMs from tumor tissues than in adjacent tissues (online supplementary figure S12B), which was corresponded to miR-99b expression in liver cancer patients, indicating that miR-99b might reprogram the TAM phenotype by regulating mTOR and/or κB-ras2 expression during tumorigenesis, and that TAM-targeted miR-99b delivery could be a potential therapy strategy for cancer in the future.