TNFRSF1A and infection: Kanaly et al. (59) showed that TNF is required for resolution of inflammatory lesions following elimination of parasites, and the lesions fail to regress in the absence of TNFR I. Taken together, IL-4–mediated inhibition of TNF production by T cells during L. major infection may be a contributing factor that promotes nonhealing infection in BALB/c mice.