Thus, DNA sensing through cGAS-STING has emerged as a triggering factor in the pathogenesis of type I interferonopathies and self-DNA inflammatory diseases, such as Aicardi-Goutières syndrome or systemic lupus erythematosus, and also with implications in cancer immunosurveillance (36, 37). This evidence concerns the gene CGAS and Aicardi-Goutieres syndrome.