INS and RASopathy: It is characterized by dysregulated insulin secretion and is classified into three main types: transient forms related to perinatal stress, infections, drugs, diffuse or focal nesidioblastosis, monogenic forms due to single-gene defects involved in insulin secretion, and those associated with syndromes such as overgrowth syndromes, like Beckwith-Wiedemann syndrome, or post-natal growth failure syndromes like RASopathies, and Kabuki make-up syndrome (KS) [4].