The top ten enriched terms KEGG pathway was shown in Fig. 2e (Legionellosis, Salmonella infection, cell cycle, cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, IL-17 signaling pathway, interleukin-4 and interleukin-13 signaling, TNF signaling, rheumatoid arthritis, and RNA transport). This evidence concerns the gene TNF and rheumatoid arthritis.