Many N1-miRs serve as putative negative regulators of genes participating cell cycle arrest and inhibiting tumor growth, including several tumor suppressors CCND1, CCND2, CDK4, CDKN1A, SESN2, SESN3, TNFRSF10B, TNRC6A/B/C, BTG2, TP53, PPP2CA. The gene discussed is CDK4; the disease is neoplasm.