To discover prognostic cancer value of SYNE3, we investigated the connection between SYNE3 expression level and DFS of patients with cancer, finding that higher SYNE3 expression brought longer lifespan to patients with renal clear cell carcinoma (KIRC) (P = 0.033, HR = 0.67) or with cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) (P = 0.046, HR = 0.56) (Additional file 2: Fig. S2a). This evidence concerns the gene SYNE3 and cancer.