TYR and melanoma: A zebrafish embryo experimental model was also employed to demonstrate antimelanogenic activity of some EOs or their components, such as that from Dalbergia pinnata, which reduced tyrosinase activity and body pigmentation in zebrafish embryos [39], and thymoquinone which blocked melanogenesis also in B16-F10 mouse melanoma cells through the inhibition of the glycogen synthase kinase 3β (GSK3β)/β-catenin pathway [224].