Boswellia carterii EO (frankincense oil) was found to induce apoptosis through downregulation of Bcl-2 and up regulation of Bax proteins in B16-F10 cells, while inducing down regulation of Mcl-1 and cleavage of caspase 3 and 9 and PARP in human melanoma FM94 cells. This evidence concerns the gene BAX and melanoma.