TNF and neoplasm: The chemopreventive effect of eugenol was due to the induction of apoptosis, prevention of oxidative stress, decrease in ornitine decarboxylase activity, attenuation of tumor inflammation caused by reduction in NF-kB pathway, COX-2 and iNOS in tumor samples and in pro-inflammatory cytokines in mice serum (e.g., IL-6, TNF-α and PGE2) [212].