Regarding EO components, several groups reported that β-elemene, one of the most active constituents of Curcuma zedoaria and Curcuma wenyujin EOs, inhibited the VEGF-induced sprouting vessel of rat aortic ring, microvessel formation of CAM, as well as CD34 and VEGF expression in C57BL/6 mice carrying B16-F10 melanoma after subretinal injection. The gene discussed is VEGFA; the disease is melanoma.