SOD1 and amyotrophic lateral sclerosis: We identified 12 index ALS cases (10 FALS and 2 SALS) with SOD1 mutations (1% of the whole cohort; 7% of all tested patients; 2% of tested SALS; 12.5% of FALS) belonging to 11 unrelated families, diagnosed by Sanger sequencing (SS) (8/145) or next generation sequencing (NGS) (4/31).