C5 and hereditary angioedema: In addition to C5 inhibitors, various complement component 1 (C1) esterase inhibitors (e.g., Berinert®, Cinryze®, Haegarda®, Ruconest®) that are used in the treatment of hereditary angioedema (HAE) have been proposed as a possible alternative to eculizumab in the treatment/prevention of aAMR and DGF [3].