IL17A and psoriasis: Kabashima’s group reported that conditional deletion of TNF receptor-associated factor 6 (TRAF6) in keratinocytes abrogated dendritic cell (DC) activation, IL-23 production, IL-17 production by γδ T cells, and subsequent IL-17-mediated psoriatic inflammation in an imiquimod psoriasis mice model; furthermore, epidermal TRAF6 was required for the full development of IL-17-mediated inflammation [70].