TNF and COVID-19: As our findings in this critical review showed that COVID-19 dysregulates the immune response which is a feature of severe disease, the immune profile of SARS-CoV-2 associated with intensive care unit (ICU) admission is related to IL-1β and IFN gamma, which correlate with Th1 response, whereas IL-4 and IL-10 correlate with Th-2 response and IL-6 and TNF-α correlate with innate response.